NU-CCNE Oligonucleotide Synthesis and Nanoconstructs Core

Primary Objectives

• To optimize and scale the spherical nucleic acid (SNA) platform for all projects in the CCNE

Approach

• Optimize constructions for intended applications (e.g., nanoparticle core composition, oligonucleotide sequence and loading, incorporation of ancillary ligands)

• Provide a standardized, scalable platform to screen in vitro efficacy of SNAs