Interdisciplinary Biological Sciences
Faculty Mentor: Chad Mirkin
Shuya Wang received a M.S. in Biotechnology from Northwestern University and a PhD in Interdisciplinary Biological Sciences. Her research is currently focused on developing the new Spherical Nucleic Acids (SNAs) structure as a cancer vaccine for immunotherapy. This research involves nanoparticle design and synthesis, cellular and animal-based immune-response evaluation, anti-tumor response evaluation, and systemic toxicity study. This work is crucial because it has discovered that structure and chemical conjugation is important in vaccine development, which previously was widely ignored by biologist and medical scientists. This study has the potential to enhance the efficacy of injectable nano-vaccines, which have seen limited success in clinical applications.
Other Awards & Fellowships
- HHMI International Student Fellowship Final List (2016-2017)
- Chemistry of Life Processes University Fellowship (2015-2016)
- Skakuj, K.; Wang, S.; Qin, L.; Lee, A.; Zhang, B.; Mirkin A. C., “Conjugation Chemistry-Dependent T‑Cell Activation with Spherical Nucleic Acids,” J. Am. Chem. Soc., 2017, 140, 1227.
- Fu, L.; Wang, S.; Wang, X.; Wang, P; Zheng, Y.; Yao, D.; Guo, M.; Zhang, L.; Ouyang, L., “Crystal Structure-based Discovery of a Novel Synthesized PARP1 Inhibitor (OL-1) with Apoptosis-inducing Mechanisms in Triple-negative Breast Cancer,” Scientific Reports, 2016, DOI: 10.1038/s41598-016-0007-2.
- Chen, Y.; Wang, S.; Zhang, L.; Xie, T.; Song, S.; Huang, J.; Zhang, Y.; Ouyang, L.; Liu, B., “Identification of ULK1 as a Novel Biomarker Involved in miR- 4487 and miR-595 regulation in Neuroblastoma SHSY5Y Cell Autophagy,” Scientific Reports, 2015, DOi: 10.1038/srep11035.
- Wang, S.; Yu, Q.; Zhang, R.; Liu, B., “Core Signaling Pathways of Survival/Death in Autophagy Related Cancer Networks,” International Journal of Biochemistry & Cell Biology. 2011, 43, 1263.
- Wang, S.; Yu, Q.; Bao, J.; Liu, B., “Polygonatum Cyrtonema Lectin, a Potential Antineoplastic Drug Targeting Programmed Cell Death Pathways,” Biochemical and Biophysical Research Communications, 2011, 406, 497
- Wen, X.; Wang, S.; Ouyang, L.; Liu, B., “Programmed Cell Death in Cancer: Targeting Apoptosis and Autophagy Pathways as Therapeutic Strategies,” Cancer and Anti-cancer drugs, Nova Science Publishers, 2012).
- Wang, S.; Chen Y.; Wang, S.; Li, P.; Mirkin C. A.; Farha, O. K., “DNA-Functionalized Metal−Organic Framework Nanoparticles for Intracellular Delivery of Proteins,” J. Am. Chem. Soc., 2019, Accepted. DOI: 10.1021/jacs.8b12705
- Wang, S.; McGuirk C. M.; Ross B. M.; Wang, S.; Chen, PC.; Xing, H.; Liu, Y.; Mirkin, C. A., “General and Direct Method for Preparing Oligonucleotide-Functionalized Metal–Organic Framework Nanoparticles,” J. Am. Chem. Soc., 2017, 139, 9827.
- Dennis, L. K.; Saadalla, A.; Blatner, R. N.; Wang, S.; Venkateswaran, V.; Gounari, F.; Cheroutre, H.; Weaver, T. C.; Roer, A.; Egilmez, K. N.; Khazaie, K., “T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine,” Cancer Immunology Research, 2015, DOI: 10.1158/2326-6066.CIR-14-0169.
- Dennis, L. K.; Wang, Y.; Blatner, R. N.; Wang, S.; Saadalla, A.; Trudeau, E.; Roers, A.; Weaver, T. C.; Lee, J. J.; Gilbert, A. J.; Chang, B. E.; Khazaie, K., “Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10-Producing T Cells,” Cancer Research, 2013, 73, 5905
- Shuya Wang; Kacper Skakuj; Gokay Yamankurt; Andrew Lee; Lei Qin; Bin Zhang; Chad A. Mirkin, “Structure-Function Relationships in the Development of Immunotherapeutic Agents,” NU Reference Nos 2017-215-02.
- Chad A. Mirkin; Kacper Skakuj; Shuya Wang, “Conjugation of Peptides to Spherical Nucleic Acids (SNAs) using Traceless Linker,” NU Reference Nos 2017-092.
- Jason A. Wertheim; Chenxia Monica Guan; Lisa Cole; Jennifer Rachel Ferrer; Gokay Yamankurt; Shuya Wang, “Therapeutic Effects of Cellular Delivery of Small Molecules and Macromolecules with Liposomal Spherical Nucleic Acids,” NU Reference Nos. 2016-161-01 & NU2016-161-02.