Grainger Distinguished Chair in Engineering
Professor of Bioengineering, Chemistry, Electrical and Computer Engineering
Member of the Beckman Institute, the Micro/Nanotechnology Lab, and the Institute for Genomic Biology
University of Illinois at Urbana-Champaign
Nano-enabled Chemotherapy and Chemo-immunotherapy for Pancreas and Solid Cancers
Nanotechnology is an area of considerable current interest in chemistry, engineering, and medicine because of its broad applications in molecular imaging, in-vitro diagnostics, targeted therapy, and image-guided surgery. The basic rationale is that nanometer-sized particles such as quantum dots, colloidal gold, and polymeric nanomicelles have functional and structural properties that are not available from either discrete molecules or bulk materials. When conjugated with targeting ligands such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target malignant tumor cells and the tumor microenvironment (such as tumor stroma and tumor vasculatures) with high specificity and affinity. In the “mesoscopic” size range of 10-100 nm, nanoparticles also have large surface areas for conjugating to multiple diagnostic and therapeutic agents, opening new possibilities in imaging, therapy, and surgery. At the present, however,
there are several fundamental problems and technical barriers that must be understood and overcome. In this talk, Nie will discuss the major challenges and opportunities in the development of technology for single-molecule spectroscopy, intraoperative cancer detection, and image-guided precision surgery. This work was supported by grants from the US National Institutes of Health (U54 CA119338, RC2 CA148265, and R01CA163256).
Dr. Shuming Nie is the Grainger Distinguished Chair in Engineering and Professor of Bioengineering, Chemistry, Materials Science and Engineering, and Electrical and Computer Engineering at the University of Illinois at Urbana-Champaign and Founding Dean of the College of Engineering and Applied Sciences at Nanjing University (China). His academic research is in the areas of nanomedicine; image-guided cancer surgery; cell-based immunotherapy; wearable optoelectronic devices and digital health. His major academic achievements include the discovery of colloidal metal nanoparticles that are able to amplify the efficiencies of surface-enhanced Raman scattering (SERS) by 14-15 orders of magnitude, his pioneering work on water-soluble semiconductor quantum dots for biomedical applications, and his breakthrough work in developing multifunctional smart nanoparticles for integrated biomedical imaging and therapy, including image-guided cancer surgery. Professor Nie has published over 350 papers, patents, and book chapters, delivered more
than 500 invited lectures around the world, and trained over 30 doctoral students and postdoctoral fellows who are now making an impact at top academic institutions and biotech companies. His scholarly work has been cited 66,000 times according to Google Scholar. Professor Nie received his BS degree from Nankai University (China) in 1983, earned his MS and PhD degrees from Northwestern University (1984-1990), and did postdoctoral research at Georgia Institute of Technology and Stanford University (1990-1994).