Adam Silverman

Chemical & Biological Engineering

Faculty Mentors: Michael Jewett and Julius Lucks

Research

Adam Silverman received a B.S .in Chemical Engineering from Georgia Tech. His research is currently focused on developing inexpensive and user-friendly diagnostics for detecting pollutants in drinking water by harnessing natural biological sensors from bacteria and using them to produce outputs that are visible to the naked eye.

Awards & Fellowships

• National Institutes of Health Biotechnology Training Program Trainee (2017-2018)
• Cabell Fellowship (2016)
• George C. Thodos Teaching Assistant Award (2018)

Publications

1. Silverman, A. D.;  Kelley-Loughnane, N.;  Lucks, J. B.; Jewett, M. C., “Deconstructing Cell-Free Extract Preparation for in Vitro Activation of Transcriptional Genetic Circuitry,” ACS Synthetic Biology,2019, 8 (2), 403-414.
2. McNerney, M. P.;  Zhang, Y.;  Steppe, P.;  Silverman, A. D.;  Jewett, M. C.; Styczynski, M. P., “Point-of-care Biomarker Quantification Enabled by Sample-specific Calibration,” Science Advances,2019, 5 (9), eaax4473.
3. Silverman, A.D.; A.S. Karim; and M.C. Jewett, “Cell-free Gene Expression: An Expanded Repertoire of Applications,” Nature Reviews Genetics, 2019. In press.
4. Meyer, A.;  Saaem, I.;  Silverman, A.;  Varaljay, V. A.;  Mickol, R.;  Blum, S.;  Tobias, A. V.;  Schwalm, N. D.;  Mojadedi, W.;  Onderko, E.;  Bristol, C.;  Liu, S.;  Pratt, K.;  Casini, A.;  Eluere, R.;  Moser, F.;  Drake, C.;  Gupta, M.;  Kelley-Loughnane, N.;  Lucks, J. P.;  Akingbade, K. L.;  Lux, M. P.;  Glaven, S.;  Crookes-Goodson, W.;  Jewett, M. C.;  Gordon, D. B.; Voigt, C. A., “Organism Engineering for the Bioproduction of the Triaminotrinitrobenzene (TATB) Precursor Phloroglucinol (PG),” ACS Synthetic Biology,2019, 8 (12), 2746-2755.
5. Thavarajah, W.; Silverman, A. D.; Verosloff, M.; Kelley-Loughnane, N.; Jewett, M. C.; Lucks, J. B., “Point-of-Use Detection of Environmental Fluoride via a Cell-Free Riboswitch-Based Biosensor, ACS Synthetic Biology,2019. In press.
6. Liu, X.; Silverman, A. D.; Alam, K. K.; Iverson, E.; Lucks, J. B.; Jewett, M. C.; Raman, S. Design of a Transcriptional Biosensor for the Portable, On-demand Detection of Cyanuric Acid, ACS Synthetic Biology,2019. In press.
7. Silverman, A.D.; Akova, U.; Alam, K.K.; Jewett, M.C.; Lucks, J.B., “Design and Optimization of a Cell-free Atrazine Biosensor, bioRxiv, 2019.

Inventions

• “On-Demand, Portable Molecular Sensing Platform,” Jewett, M.C.; Lucks, J.B.; Silverman, A.D.; Alam, K.K., Serial No. 62/714,427, August 3, 2018.  
• “Riboswitch-based Fluoride Sensing in Cell-free Extract,” Lucks, J.B.; Jewett, M.C.; Silverman, A.D.; Thavarajah, W., Serial No. 62/813,368, March 4, 2019.
• “Ultrasensitive and Multiplexed Cell-free Biosensors Using Cascaded Amplification and Positive Feedback,” Lucks, J.B.; Jewett, M.C.; Silverman, A.D., Provisional filed December 4, 2019.